# konfound

In social science (and educational) research, we often wish to understand how robust inferences about effects are to unobserved (or controlled for) covariates, possible problems with measurement, and other sources of bias. The goal of `konfound`

is to carry out sensitivity analysis to help analysts to *quantify how robust inferences are to potential sources of bias*. This R package provides tools to carry out sensitivity analysis as described in Frank, Maroulis, Duong, and Kelcey (2013) based on Rubin’s (1974) causal model as well as in Frank (2000) based on the impact threshold for a confounding variable.

# Installation

You can install konfound with:

`install.packages("konfound")`

You can install the development version from GitHub with:

```
install.packages("devtools")
devtools::install_github("jrosen48/konfound")
```

```
#> Loading konfound
#> Sensitivity analysis as described in Frank, Maroulis, Duong, and Kelcey (2013) and in Frank (2000).
#> For more information visit http://konfound-it.com.
```

# Use of konfound

#### pkonfound() for published studies

`pkonfound()`

, for published studies, calculates (1) how much bias there must be in an estimate to invalidate/sustain an inference; (2) the impact of an omitted variable necessary to invalidate/sustain an inference for a regression coefficient:

`library(konfound)`

```
pkonfound(est_eff = 2,
std_err = .4,
n_obs = 100,
n_covariates = 3)
#> Percent Bias Necessary to Invalidate the Inference:
#> To invalidate an inference, 60.3% of the estimate would have to be due to bias. This is based on a threshold of 0.794 for statistical significance (alpha = 0.05).
#> To invalidate an inference, 60 observations would have to be replaced with cases for which the effect is 0.
#>
#> Impact Threshold for a Confounding Variable:
#> An omitted variable would have to be correlated at 0.568 with the outcome and at 0.568 with the predictor of interest (conditioning on observed covariates) to invalidate an inference based on a threshold of 0.201 for statistical significance (alpha = 0.05).
#> Correspondingly the impact of an omitted variable (as defined in Frank 2000) must be 0.568 X 0.568 = 0.323 to invalidate an inference.
#> For other forms of output, change `to_return` to table, raw_output, thres_plot, or corr_plot.
#> For models fit in R, consider use of konfound().
```

#### konfound() for models fit in R

`konfound()`

calculates the same for models fit in R. For example, here are the coefficients for a linear model fit with `lm()`

using the built-in dataset `mtcars`

:

```
m1 <- lm(mpg ~ wt + hp, data = mtcars)
m1
#>
#> Call:
#> lm(formula = mpg ~ wt + hp, data = mtcars)
#>
#> Coefficients:
#> (Intercept) wt hp
#> 37.22727 -3.87783 -0.03177
summary(m1)
#>
#> Call:
#> lm(formula = mpg ~ wt + hp, data = mtcars)
#>
#> Residuals:
#> Min 1Q Median 3Q Max
#> -3.941 -1.600 -0.182 1.050 5.854
#>
#> Coefficients:
#> Estimate Std. Error t value Pr(>|t|)
#> (Intercept) 37.22727 1.59879 23.285 < 2e-16 ***
#> wt -3.87783 0.63273 -6.129 1.12e-06 ***
#> hp -0.03177 0.00903 -3.519 0.00145 **
#> ---
#> Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
#>
#> Residual standard error: 2.593 on 29 degrees of freedom
#> Multiple R-squared: 0.8268, Adjusted R-squared: 0.8148
#> F-statistic: 69.21 on 2 and 29 DF, p-value: 9.109e-12
```

Sensitivity analysis for the effect for `wt`

on `mpg`

can be carried out as follows, specifying the fitted model object:

```
konfound(m1, wt)
#> Percent Bias Necessary to Invalidate the Inference:
#> To invalidate an inference, 66.664% of the estimate would have to be due to bias. This is based on a threshold of -1.293 for statistical significance (alpha = 0.05).
#> To invalidate an inference, 21 observations would have to be replaced with cases for which the effect is 0.
#>
#> Impact Threshold for a Confounding Variable:
#> An omitted variable would have to be correlated at 0.787 with the outcome and at 0.787 with the predictor of interest (conditioning on observed covariates) to invalidate an inference based on a threshold of -0.36 for statistical significance (alpha = 0.05).
#> Correspondingly the impact of an omitted variable (as defined in Frank 2000) must be 0.787 X 0.787 = 0.619 to invalidate an inference.
#> For more detailed output, consider setting `to_return` to table
#> To consider other predictors of interest, consider setting `test_all` to TRUE.
```

#### mkonfound for meta-analyses including sensitivity analysis

We can use an existing dataset, such as the CSV file here.

```
d <- read.csv("https://msu.edu/~kenfrank/example%20dataset%20for%20mkonfound.csv")
head(d)
#> t df
#> 1 7.076763 178
#> 2 4.127893 193
#> 3 1.893137 47
#> 4 -4.166395 138
#> 5 -1.187599 97
#> 6 3.585478 87
mkonfound(d, t, df)
#> # A tibble: 30 x 7
#> t df action inference pct_bias_to_change_i… itcv r_con
#> <dbl> <int> <chr> <chr> <dbl> <dbl> <dbl>
#> 1 7.08 178 to_invali… reject_null 68.8 0.378 0.614
#> 2 4.13 193 to_invali… reject_null 50.6 0.168 0.41
#> 3 1.89 47 to_sustain fail_to_reje… 5.47 -0.012 0.11
#> 4 -4.17 138 to_invali… reject_null 50.3 0.202 0.449
#> 5 -1.19 97 to_sustain fail_to_reje… 39.4 -0.065 0.255
#> 6 3.59 87 to_invali… reject_null 41.9 0.19 0.436
#> 7 0.282 117 to_sustain fail_to_reje… 85.5 -0.131 0.361
#> 8 2.55 75 to_invali… reject_null 20.6 0.075 0.274
#> 9 -4.44 137 to_invali… reject_null 53.0 0.225 0.475
#> 10 -2.05 195 to_invali… reject_null 3.51 0.006 0.077
#> # … with 20 more rows
```

# Other information

### How to learn more about sensitivity analysis

To learn more about sensitivity analysis, please visit:

- The Introduction to konfound vignette, with detailed information about each of the functions (
`pkonfound()`

,`konfound()`

, and`mkounfound()`

) - The causal inference section of Ken Frank's website here
- The konfound interactive web application, with links to PowerPoints and key publications

### Feedback, issues, and feature requests

We prefer for issues to be filed via GitHub (link to the issues page for `konfound`

here) though we also welcome questions or feedback via email.

### Code of Conduct

Please note that this project is released with a Contributor Code of Conduct available at http://contributor-covenant.org/version/1/0/0/