LastFmApi
A thin but dynamic wrapper around the Last.fm api webservice found at http://ws.audioscrobbler.com/2.0/ - Currently, only unauthenticated endpoints are supported. You are still required to provide an API key just not the secret.
Installation is easy.
pip install lastfmapi
Once that's done, you can do something as simple as...
import lastfmapi
api = lastfmapi.LastFmApi('<your api key here>')
api.album_getInfo(artist='Cher', album='Believe')
For methods on the Last.fm api, simply call that method on the api object, subsituting '_' where '.' would be.