Peek
This project is still under development
Peek is a profiling tool which aims to help you track down the core performance problems in your Python application.
It does this by installing a trace hook, which looks at every Python call (similar to line_profiler), and records how long that call took.
Credits
The implementation of the tracer and several of the "hacks" required to get things like this in place are heavily inspired by Ned Batchelder's coverage.py project.